But what if cancer isn't a genetic disease after all? What if scientists are chasing a flawed paradigm, and cancer isn't a disease of damaged DNA but rather of defective metabolism as a result of mitochondrial dysfunction? What if that startling truth could revolutionize our understanding of other diseases as well--and show us a radical new path to optimal health? In this groundbreaking guide, the first of its kind, New York Times best-selling author and leading natural-health practitioner Joseph Mercola explains how nearly all disease is caused by defective metabolic processes.
Then he reveals what's really causing your metabolism to go haywire: damage and dysfunction in the mitochondria, thousands of which are at work in nearly every cell in your body, generating 90 percent of the energy you need to stay alive and well. When mitochondria become damaged in large numbers, it is impossible to stay healthy.
You can do a traditional 2- to 3-day water fast where you drink nothing but water plus minerals, or you can take your pick of at least 5 other types of fasts to make the transition to fat-burning even easier.
As I show in Fat for Fuel, switching to burning fat as your primary fuel is a very powerful strategy for improving the health of your mitochondria, and in turn, your overall health. In Fat for Fuel, I help you determine how long is enough for you based on your genetic and mitochondrial differences, as well as any hormonal challenges you may have.
MMT is not intended to be a long-term deprivation diet. There are multiple ways to use this clever strategy and I review them all in Fat for Fuel. The first two are the foods you eat and when you eat them. You could even be following my MMT eating plan and be at high risk for this health-wrecking threat!
Excess iron can lead to one of the most dangerous reactions in your body — the Fenton reaction — that decimates your mitochondrial DNA, proteins, and membranes and contributes to system-wide inflammation. And all you may initially notice is some joint pain, fatigue, gut pain, memory fog, or an irregular heartbeat!
Even moderately elevated levels of iron can contribute to:. Fat for Fuel is your guide to repairing and nourishing your mitochondria. Without question, my MMT diet is the most effective way to improve the health of your mitochondria. At least half of them you can do at home without any special tools or equipment! In this bonus chapter, I show you:.
If all you want are some smart but quick fixes, this is not the right book for you. Effortless Healing walks you through nine powerful principles or steps that you can apply right away to your daily life to create healthy new habits and radically improved health. Or you can go to Mercola. Fat for Fuel digs deeper — much deeper — into the very source of cancer, obesity, diabetes, mental decline and other chronic diseases that are affecting Westerners especially in epidemic numbers.
And it provides a real solution that works. If you agree with just one of these statements, then I can assure you there is solid value waiting for you within the covers of Fat for Fuel.
He states:. This is a life-changing text that not only provides a deep dive into why choosing fat as our primary fuel source powerfully correlates with health and disease resistance, but also delivers in terms of how the reader can easily bring about this fundamentally important change. Maybe you feel like you have time to wait before making profound changes to your health. Your body is producing fewer mitochondria, so that puts you at a disadvantage right from the gate.
Time really may not be on your side. Just about everyone has at least some. Why wait when you can start making powerful changes now in your mitochondrial health? Changes that will have a ripple effect throughout your entire body. Joseph Mercola is a physician and New York Times best-selling author. Oz Show. His mission is to transform the traditional medical paradigm in the United States into one in which the root cause of disease is treated, rather than the symptoms.
In addition, he aims to expose corporate and government fraud and mass media hype that often sends people down an unhealthy path. By continuing to browse our site you agree to our use of cookies, revised Privacy Policy and Terms of Service.
I agree. Fat for Fuel. Joseph Mercola has been a shining beacon of health wisdom and freedom for decades. Fat for Fuel is a masterpiece of cutting-edge research and practical application. I never learned anything about the root cause of chronic disease in med school.
In other words, getting cancer is not God's will. Charles, MO. NEFAs and leptin were determined arterial catheter was maintained by means of a slow infusion of saline using commercial kits Boehringer Mannheim, KK, Tokyo recombinant rat solution. In a first series of experiments, four groups of six animals each were Statistical analysis. The level of started and continued at a rate of 0. Blood samples were collected before and after 3 and 24 h of infusion to determine blood glucose, plasma insulin, NEFA, and leptin concentrations.
Intralipid plus heparin infusion see below. After a 3- comparison with the saline plus heparin—treated rats, but or h infusion period, the rats were killed, and tissues were removed for no significant differences in blood glucose were observed quantification of gene expression.
Intralipid treatment was also followed by a UCP2, and UCP3 mRNA levels were assessed in various muscles and visceral significant increase in serum leptin levels, which was fat by means of Northern blotting or reverse transcriptase—polymerase chain reaction RT-PCR analysis see below.
No significant Tissue glucose utilization index. The glucose utilization index was as- differences in food intake and body weight were noted sessed at the end of a euglycemic-hyperinsulinemic clamp. A primed contin- between the two groups of animals data not shown. Glucose infusion rate and tissue glucose utilization appears to be modulated by calorie intake of fat 23 , we index during a euglycemic-hyperinsulinemic clamp. Figure 1 shows that the glucose utilization index was significantly reduced in the same animals in all of the oxidative muscles considered the red portion of the quadriceps and gastroc- nemius, and the soleus after both 3 Table 2 and 24 h Fig.
Increased NEFA availability was followed by an enhanced glucose uptake in visceral adi- pose tissue after 3 Table 2 and 24 h Fig. On the basis of these results, the following experiments were performed only in visceral fat and red fiber—type muscle soleus. Effects of Intralipid plus heparin infusion on gene expression in visceral fat and red fiber—type skeletal muscle. Figure 3A shows that the enhancement of glucose uptake observed after Intralipid plus heparin infusion was paralleled by increased GLUT4 expression in visceral fat after 24 h.
Glucose utilization index measured in various skeletal muscles levels by RT-PCR after Intralipid plus heparin infusion. Leptin gene expression in muscle was which was probably due to increased lipid use by red detected by RT-PCR only after 24 h of Intralipid infusion fiber—type muscles , insulin resistance develops as a result but was undetectable at baseline and after 3 h Fig. These results are in line with the reported NEFA uptake [25] was evident in rat muscle after 3 h of observation that high-fat feeding leads to increased leptin infusion, and red fiber—type muscle insulin-dependent glu- gene expression in rat adipose tissue and muscle Figure 5D shows that the under baseline conditions was markedly enhanced.
Our findings suggest that greater NEFA availability may shift red fiber—type muscle metabolism to preferential use of lipids rather than carbo- hydrates as fuel substrates. There is a simultaneous increase in the insulin sensitiv- ity of visceral but not subcutaneous fat. GLUT4 favors glucose utilization, whereas one animal. Kubota et al. This is consistent with the fact that thiazolidine- muscle and increased plasma leptin levels. Lowell ing in vivo tissue triglyceride stores 47, Furthermore, leptin disease when food is plentiful.
J Clin Invest —, energy expenditure 50 , and insulin signaling 51, Diabetes —, effect on food intake, leptin leads to a marked improve- 4. Randle PJ, Garland PB, Hales CN, Newsholme EA: The glucose fatty acid ment in insulin sensitivity and glucose disposal in a mouse cycle: its role in insulin sensitivity and the metabolic disturbances of model of lipodistrophy Leptin expression in the fat diabetes mellitus.
Lancet i—, and muscle of subjects with high circulating NEFA levels 5. Nature could therefore be involved in counterbalancing excessive — , fat accumulation and the development of insulin resis- 6. Diabetes —, and muscle. These findings are in line with the enhanced 8. FEBS Lett monly high. Nat Genet rat skeletal muscle This molecular event may be —, ultimately aimed at dissipating energy excess, but UCP2
0コメント